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In some embodiments, the otic pharmaceutical formulation comprises about 62% by weight of the triglycerides

10.7860/JCDR/2013/6035.3331 34

Steric hindrance from the increased side-chain volume of E14 Cagri and R17 Cagri promotes a shift of the -helix of Cagri away from ECL2 and a slight expansion of the peptide binding pocket at the extracellular side of the CTR TM domain, relative to those observed with rAmy/San385-bound AMYR complexes

Each cartridge is available in 5mg and 100mg options, offered individually or as part of a complete kit that includes a reusable pen, needle tips, and a carry case for convenient and precise preparation